Post-synthetic modification of oligonucleotides containing 5-mono- and 5-di-fluoromethyluridines
نویسندگان
چکیده
منابع مشابه
Insights into the soluble PEG-supported synthesis of cytosine-containing nucleoside 5'-mono-, di-, and triphosphates.
Nucleoside phosphoesters (nucleotides) have crucial roles in a large variety of biological processes including nucleic acid biosynthesis and their corresponding analogues are extensively used as biological tools. Herein, we describe a new and efficient synthetic procedure involving polyethylene glycol (PEG) as soluble support and regioselective mono-, di-, and triphosphorylation steps. Applied ...
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2021
ISSN: 0040-4020
DOI: 10.1016/j.tet.2020.131769